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PROSTATE CANCER SCREENING:
(March 2003) Healthful Life has maintained that we do not know how to prevent prostate cancer and screening with the blood test called prostate specific antigen (PSA) or with the digital rectal examination has not been shown to save lives or prolong good quality life. We do not recommend the test - and we will not until the two major studies, one in the United States and one in Europe, now in progress, give us a definitive answer as to whether doing PSA testing does or does not save lives or significantly prolong life. On December 8, 2002, the well-respected US Preventive Services Task Force reported its new recommendations in the Annals of Internal Medicine. This was accompanied by a lot of media coverage. One headline declared "Government drops objection to prostate test". Another said "panel softens prostate screening stance". In 1996, the panel had given the PSA test a "D" rating, meaning the evidence suggested the test should not be done. Here is what the Task Force said. "No conclusive direct evidence shows that screening reduces prostate cancer mortality. Although potential harms of screening for prostate cancer can be established, the presence or magnitude of potential benefits cannot. Therefore, the net benefit of screening cannot be determined." "Screening is associated with important harms, including frequent false-positive results and unnecessary anxiety, biopsies, and potential complications of treatment of some cases of cancer that may never have affected a patients health. The Task Force concludes that evidence is insufficient to determine whether the benefits outweigh the harms for a screened population." "The Task Force concludes that the evidence is insufficient to recommend for or against routine screening for prostate cancer using PSA or digital rectal examination." There you have it. In 1996, the Task Force said do not do it, in 2002, they say we do not know whether screening is beneficial and the harms may outweigh any benefits. In essence, the Task Force and Healthful Life are in agreement, but the advice for doctors and the public by the Task Force and other organizations in writing and in media interviews is sort of strange. They recommend doctors inform men of the "gaps in knowledge", "assist men in their personal preferences" (consider mens personal preferences). What those difficult to interpret phrases really mean, as stated more clearly in interviews, is that men should be given the confusing information and be urged to educate themselves so they can make an "informed" decision about undergoing the PSA test, thus relieving the doctors of responsibility for those decisions. So, the men are supposed to review the conflicting articles, interpret the epidemiology findings and the complex statistics, and then decide whether to undergo PSA tests. If the US Preventive Services Task Force cannot find benefit and can find harms from screening, they and other organizations should, like Healthful Life, just say we do not recommend the PSA test and they should not pass the burden to men to make an "informed" decision. A few final points. - If those urging PSA tests point to declining deaths from prostate cancer in the United States, they are correct. Some attribute this to PSA screening. BUT, in England, the same decline in deaths has occurred and they do not have widespread PSA testing. - Most advocates of the PSA test agree there is no likely benefit from detecting cancer in men over age 70. Men over 70 should certainly not be tested (and that may apply to those over age 65 as well). - If men decide to ignore our recommendation for no PSA testing until the definitive studies are completed, they should realize that, if these studies eventually do show benefit, the age group showing the benefit of screening is likely to be 50 to 64 years (or perhaps 50 to 69 years). - Of those undergoing treatment for very early cancers detected by PSA tests, a very substantial percentage will have significant complications, including incontinence and impotence. - In regard to the new studies now being conducted of vitamin E and selenium as possible preventives for prostate cancer, Healthful Life believes there is very little likelihood vitamin E will be helpful and that selenium will either show no benefit or only a small reduction in risk of prostate cancer. |
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